High Mass Accuracy Phosphopeptide Identification Using Tandem Mass Spectra
نویسندگان
چکیده
منابع مشابه
High Mass Accuracy Phosphopeptide Identification Using Tandem Mass Spectra
Phosphoproteomics is a powerful analytical platform for identification and quantification of phosphorylated peptides and assignment of phosphorylation sites. Bioinformatics tools to identify phosphorylated peptides from their tandem mass spectra and protein sequence databases are important part of phosphoproteomics. In this work, we discuss general informatics aspects of mass-spectrometry-based...
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Mass spectrometry has played a significant role in the identification of unknown phosphoproteins and sites of phosphorylation in biological samples. Analyses of protein phosphorylation, particularly large scale phosphoproteomic experiments, have recently been enhanced by efficient enrichment, fast and accurate instrumentation, and better software, but challenges remain because of the low stoich...
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SUMMARY Tandem mass spectra obtained from fragmenting peptide ions contain some peptide sequence specific information, but often there is not enough information to sequence the original peptide completely. Several proprietary software applications have been developed to attempt to match the spectra with a list of protein sequences that may contain the sequence of the peptide. The application TA...
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This paper presents an interdisciplinary investigation of statistical information retrieval (IR) techniques for protein identification from tandem mass spectra, a challenging problem in proteomic data analysis. We formulate the task as an IR problem, by constructing a “query vector” whose elements are system-predicted peptides with confidence scores based on spectrum analysis of the input sampl...
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ژورنال
عنوان ژورنال: International Journal of Proteomics
سال: 2012
ISSN: 2090-2166,2090-2174
DOI: 10.1155/2012/104681